Lismore's rich natural history is closely tied to the once vast rainforest known as the "Big Scrub", a lush and biodiverse region that covered much of the area before British settlement. Tragically, less than 1% of the original rainforest remains today, but parts of it can still be explored. Wilsons Nature Reserve on Wyrallah Road and the grounds of Southern Cross University offer a glimpse into this important ecological heritage, showcasing sections of the Big Scrub's unique rainforest.

Geographically, Lismore is strategically positioned at the confluence of the Wilsons River and Leycester Creek, both tributaries of the larger Richmond River. The city lies 35 km (22 miles) from the eastern coast, nestled within the fertile Northern Rivers region of New South Wales. It is located 764 km (475 miles) to the north of Sydney and 200 km (124 miles) south of Brisbane, making it a key regional hub.

Lismore is 46 km (29 miles) southwest of Byron Bay and just 36 km (22 miles) from the coastal town of Ballina, offering residents and visitors easy access to both hinterland landscapes and coastal experiences. The region also boasts remnants of the Big Scrub, with patches of rainforest preserved in locations such as the Boatharbour Reserve on the Bangalow road.

Nearby, the Nightcap National Park offers a larger and publicly accessible natural sanctuary, providing opportunities for hiking, birdwatching, and experiencing the region's diverse flora and fauna. Together, Lismore's geography and protected natural areas make it a unique blend of rural charm and environmental significance.